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During a nearly two-decade stint as Alnylam’s founding CEO, John Maraganore took a promising but unproven approach for treating genetic disease and built a new class of medicines and what is now a nearly $21 billion company.

His next goal? Helping the next generation of budding biotech entrepreneurs.

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Since stepping down as Alnylam CEO in 2021, Maraganore has spent much of his time passing down his knowledge to up-and-coming biotech CEOs. He shared some of that wisdom on Wednesday at the 2023 STAT Summit, from thoughts on how entrepreneurs can prepare themselves for the rough-and-tumble world of drug development to tips on raising money and dealing with the Food and Drug Administration.

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